Isolation and structural elucidation of an antioxidative agent, naphterpin.

Isolation and structural elucidation of an antioxidative agent, naphterpin.

Active oxygen species cause a variety of diseases such as inflammation, autoimmune disease, diabetes, rheumatism, cardiovascular diseases and cancer-initiation1>2). Thus, it could be expected that antioxidative agents may prevent these diseases. We have screened antioxidants of microbial origin by employing the Yagi method after minor modification using rat liver microsome free from vitamin E3)...

ISOLATION AND STRUCTURAL ELUCIDATION OF THE FIRST KNOWN C-HOMOPROTOBERBERINE

A novel C-homoprotoberberine alkaloid, Hediamine (2), has been isolated from the roots of Berberis actinucantha (Berberidaceae). Conclusive proof for the structure of hediamine was obtained by its comparison with the isomeric lactam (4), by chemical transformation, and by means of spectroscopic techniques (UV, IR, MS, NMR).

Structural elucidation of three antioxidative polysaccharides from Tricholoma lobayense.

Tricholoma lobayense is a nutritious mushroom with great health benefits. Three polysaccharides with purity higher than 99% were successfully extracted from Tricholoma lobayense. The molecular weights of TLH-1, TLH-2 and TLH-3 were determined to be 8.43×105，5.36×105 and 4.53×103Da, respectively. The backbones of TLH-1 and TLH-2 were mainly composed of 1,4-linked α-d-glucopyranosyl. However, pol...

isolation and structural elucidation of natural products in euphorbia erythradenia

Fermentation, Isolation, Structural Elucidation and Biological Activities

A fermentation broth of an unidentified fungus (N983-46) was found to produce DNAgyrase inhibitors, CJ-12,371 (1) and CJ-12,372 (2). Following isolation by solvent extraction and silica gel and ODS(reverse phase) chromatographies, the structures were determined to be novel spiro-ketal compounds with S-connguration at position C-l. CJ-12,371 and CJ-12,372 inhibit both DNA supercoiling and relaxa...